SUSD4

Across TCGA patient cohorts, SUSD4 mutation is significantly associated with the RNA expression of many other genes, with 2,639 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUSD4-associated genes across cancer lineages are TTTY8, ZWINT, and CDCA8. Each is linked with SUSD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SUSD4-to-partner and partner-to-SUSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY8 grouped by SUSD4-low versus SUSD4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD4→partner) and Y-score (partner→SUSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTTY8 →	+0.039	+7.473	<.001	.007	3	4
UCEC	ZWINT →	+0.727	+2.263	<.001	<.001	3	3
UCEC	CDCA8 →	+0.633	+3.263	.002	<.001	3	3
UCEC	TROAP →	+0.549	+2.906	.004	.001	3	3
UCEC	POLA2 →	+0.503	+3.950	<.001	<.001	3	3
UCEC	DTL →	+0.651	+3.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,639 associations by consensus.

TTTY8 by SUSD4 expression — BRCA

Explore this box plot interactively →