SUSD4

Across TCGA patient cohorts, SUSD4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUSD4-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with SUSD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUSD4-to-partner and partner-to-SUSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SUSD4-low versus SUSD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD4→partner) and Y-score (partner→SUSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.163	+1.874	.021	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.661	+1.697	.002	.012	3	2
UCEC	Cyclin-B1 →	+0.615	+1.807	.002	.025	3	2
UCEC	Di-Ras3 →	-0.172	-3.794	.001	<.001	3	2
SKCM	p38-MAPK →	+0.143	+1.847	.022	.008	3	1
SKCM	p90 RSK →	+0.179	+1.807	.020	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by SUSD4 expression — UCEC

Explore this box plot interactively →