Q-omics provides the consensus-scored ST7-OT4 profile across patient tissues and cancer cell-line models. ST7-OT4 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, ST7-OT4 is differentially expressed in 13, with the highest sampling consensus in THCA. Additionally, ST7-OT4 RNA expression shows 17,559 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight BLCA, THCA, and UVM as cancer lineages where ST7-OT4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ST7-OT4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ST7-OT4 survival associations across molecular data types. ST7-OT4 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ST7-OT4 RNA expression–survival associations across cancer types. High ST7-OT4 expression shows unfavorable associations in BLCA, CESC and MESO, but favorable associations in ACC, CHOL and SKCM. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for ST7-OT4 RNA expression.
This table summarizes ST7-OT4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ST7-OT4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ST7-OT4 shows lower tumor expression in THCA and UCEC and higher tumor expression in KIRC, COAD, LIHC and LUSC. The THCA box plot shows higher ST7-OT4 RNA expression in normal versus tumor tissue (log2 FC = −0.310, t-test p < 0.001).
This table shows molecular features associated with ST7-OT4 in patient tissues and cancer cell lines. In patient samples, ST7-OT4 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ST7-OT4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE.
