SRP14-AS1

Across TCGA patient cohorts, SRP14-AS1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP14-AS1-associated genes across cancer lineages are MIR4505, IGHV1OR15-1, and BCRP6. Each is linked with SRP14-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP14-AS1-to-partner and partner-to-SRP14-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4505 grouped by SRP14-AS1-low versus SRP14-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP14-AS1→partner) and Y-score (partner→SRP14-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4505 →	+0.707	+4.778	.001	.003	3	1
UCEC	IGHV1OR15-1 →	+0.235	+5.386	<.001	.001	3	1
UCEC	BCRP6 →	+0.133	+4.661	<.001	.004	3	1
UCEC	AQP7P3 →	+0.122	+5.582	<.001	.002	3	1
UCEC	MT-TA →	+0.441	+4.484	<.001	.009	3	1
UCEC	TRAJ28 →	+0.835	+4.302	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MIR4505 by SRP14-AS1 expression — UCEC

Explore this box plot interactively →