SRP14-AS1

Across TCGA pan-cancer cohorts, SRP14-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SRP14-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SRP14-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SRP14-AS1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and KIRC are the cancer types where SRP14-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRP14-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−1.228	<.001	11	view →
THCA	Male	III,IV	−1.104	<.001	11	view →
KIRC	Male	II,III,IV	−0.786	<.001	11	view →
COAD	All	III,IV	−0.680	<.001	11	view →
LUSC	All	III,IV	−1.035	<.001	8	view →
LUAD	Female	II,III,IV	−0.745	<.001	8	view →
KICH	Female	All	−1.123	<.001	6	view →
UCEC	All	II,III,IV	−1.010	<.001	6	view →
BRCA	All	II,III,IV	−0.764	<.001	6	view →
LIHC	Male	All	+0.591	<.001	5	view →
READ	All	III,IV	−0.720	.026	3	view →
BLCA	Male	IV	−1.410	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SRP14-AS1–KIRP

Open the KIRP breakdown →