SRP14-AS1

Across TCGA pan-cancer cohorts, SRP14-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SRP14-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher SRP14-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SRP14-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and UCEC show a favorable association.

MESO, UCEC, and SKCM are the cancer types where SRP14-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.549	0.270	<.001	73	view →
UCEC	DFS	Tertile	All	0.770	0.610	.003	44	view →
SKCM	OS	Tertile	II,III,IV	0.420	0.192	.001	36	view →
LUSC	OS	Quartile	All	0.510	0.368	.004	31	view →
KIRP	DFS	Median	All	0.959	0.863	.002	30	view →
LAML	DFS	Quartile	All	0.258	0.672	<.001	30	view →
UCS	DFS	Tertile	II,III,IV	0.685	0.278	.007	26	view →
CESC	DFS	Quartile	All	0.725	0.852	.008	20	view →
PAAD	OS	Quartile	All	0.447	0.221	.012	17	view →
READ	OS	Median	All	0.866	0.960	.020	12	view →
ACC	DFS	Tertile	II,III,IV	0.273	0.656	.009	10	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.127	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SRP14-AS1–MESO (OS)

Open the MESO breakdown →