Q-omics provides the consensus-scored BCRP6 profile across patient tissues and cancer cell-line models. BCRP6 expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in DLBC. Among the 18 cancer types available for tumor–normal comparison, BCRP6 is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, BCRP6 RNA expression shows 3,752 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight DLBC, LUSC, and STAD as cancer lineages where BCRP6 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BCRP6 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BCRP6 survival associations across molecular data types. BCRP6 RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BCRP6 RNA expression–survival associations across cancer types. High BCRP6 expression shows unfavorable associations in DLBC, LIHC, CHOL and ACC, but favorable associations in HNSC and ESCA. The DLBC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify DLBC as the clearest survival context for BCRP6 RNA expression.
This table summarizes BCRP6 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for BCRP6. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BCRP6 shows higher tumor expression in LUSC. The LUSC box plot shows higher BCRP6 RNA expression in tumor versus normal tissue (log2 FC = +0.035, t-test p = .017).
This table shows molecular features associated with BCRP6 in patient tissues and cancer cell lines. In patient samples, BCRP6 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
