spindlin family member 4Genealiases: LJBS · TDRD28
Q-omics provides the consensus-scored SPIN4 profile across patient tissues and cancer cell-line models. SPIN4 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SPIN4 is differentially expressed in 16, with the highest sampling consensus in COAD. Additionally, SPIN4 RNA expression shows 20,533 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and COAD as cancer lineages where SPIN4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPIN4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPIN4 survival associations across molecular data types. SPIN4 RNA expression shows survival associations in the most cancer types (29), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPIN4 RNA expression–survival associations across cancer types. High SPIN4 expression shows unfavorable associations in ACC, MESO, LGG, LIHC and LUAD, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for SPIN4 RNA expression.
This table summarizes SPIN4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 1. The strongest signals are observed in COAD for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for SPIN4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPIN4 shows lower tumor expression in KICH and higher tumor expression in COAD, LIHC, KIRP, BRCA and CHOL. The COAD box plot shows higher SPIN4 RNA expression in tumor versus normal tissue (log2 FC = +1.598, t-test p < 0.001).
This table shows molecular features associated with SPIN4 in patient tissues and cancer cell lines. In patient samples, SPIN4 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, SPIN4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
