spindlin family member 2BGenealiases: SPIN-2 · SPIN-2B · SPIN2_duplicate · TDRD26 · dJ323P24.2
Q-omics provides the consensus-scored SPIN2B profile across patient tissues and cancer cell-line models. SPIN2B expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in PAAD. Among the 18 cancer types available for tumor–normal comparison, SPIN2B is differentially expressed in 9, with the highest sampling consensus in KICH. Additionally, SPIN2B RNA expression shows 19,458 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight PAAD, KICH, and UVM as cancer lineages where SPIN2B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPIN2B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPIN2B survival associations across molecular data types. SPIN2B RNA expression shows survival associations in the most cancer types (22), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPIN2B RNA expression–survival associations across cancer types. High SPIN2B expression shows unfavorable associations in LIHC, UVM and ESCA, but favorable associations in PAAD, MESO and LUSC. The PAAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify PAAD as the clearest survival context for SPIN2B RNA expression.
This table summarizes SPIN2B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for SPIN2B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPIN2B shows lower tumor expression in KICH and THCA and higher tumor expression in LIHC, COAD, HNSC and KIRP. The KICH box plot shows higher SPIN2B RNA expression in normal versus tumor tissue (log2 FC = −0.778, t-test p < 0.001).
This table shows molecular features associated with SPIN2B in patient tissues and cancer cell lines. In patient samples, SPIN2B shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, SPIN2B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia.
