Across TCGA pan-cancer cohorts, SPIN2B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPIN2B data layer compared with 2 for mutation status.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher SPIN2B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPIN2B expression acts as an unfavorable survival marker, although some lineages such as PAAD and MESO show a favorable association.
PAAD, LIHC, and UVM are the cancer types where SPIN2B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.