Across TCGA pan-cancer cohorts, SPIN2B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPIN2B data layer compared with 22 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPIN2B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPIN2B expression acts as an unfavorable survival marker.

ACC and LUSC are the cancer types where SPIN2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.057	0.667	<.001	15	view →
LUSC	DFS	Median	All	0.136	0.758	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SPIN2B tumor-vs-normal RNA expression · all SPIN2B data types