Across TCGA patient cohorts, SPIN2B mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIN2B-associated genes across cancer lineages are STAT3_pY705, VEGFR2, and PDCD4. Each is linked with SPIN2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIN2B-to-partner and partner-to-SPIN2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN2B→partner) and Y-score (partner→SPIN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.440	-3.000	.003	.037	3	1
UCEC	VEGFR2 →	+0.392	+3.013	.022	.019	3	1
UCEC	PDCD4 →	-0.703	-3.000	.009	.037	2	1
UCEC	EGFR_pY1068 →	-0.318	-3.000	.028	.037	1	1
UCEC	MEK1 →	+0.477	+3.000	.024	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

SPIN2B survival (RNA) · tumor vs normal (RNA) · all SPIN2B data types