Q-omics provides the consensus-scored SMKR1 profile across patient tissues and cancer cell-line models. SMKR1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SMKR1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, SMKR1 RNA expression shows 16,956 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRP, COAD, and LSCC as cancer lineages where SMKR1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SMKR1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SMKR1 survival associations across molecular data types. SMKR1 RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SMKR1 RNA expression–survival associations across cancer types. High SMKR1 expression shows unfavorable associations in KIRP, KIRC, MESO, LGG and LIHC, but favorable associations in ACC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SMKR1 RNA expression.
This table summarizes SMKR1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for SMKR1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SMKR1 shows lower tumor expression in KICH and higher tumor expression in COAD, LUAD, BLCA, HNSC and LIHC. The COAD box plot shows higher SMKR1 RNA expression in tumor versus normal tissue (log2 FC = +2.186, t-test p < 0.001).
This table shows molecular features associated with SMKR1 in patient tissues and cancer cell lines. In patient samples, SMKR1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SMKR1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BONE.
