SLC6A12

Across TCGA cell cohorts, SLC6A12 mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A12-associated genes across cancer lineages are DEUP1, OR4N4, and KLK12. Each is linked with SLC6A12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A12-to-partner and partner-to-SLC6A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEUP1 grouped by SLC6A12-low versus SLC6A12-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A12→partner) and Y-score (partner→SLC6A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DEUP1 →	+0.178	+3.754	.001	.008	3	2
SOFT_TISSUE	OR4N4 →	+0.061	+4.930	<.001	.008	3	1
SOFT_TISSUE	KLK12 →	+0.804	+4.930	<.001	.008	3	1
SOFT_TISSUE	ASCL4 →	+0.016	+4.930	<.001	.008	3	1
OESOPHAGUS	USP17L20 →	+0.050	+4.906	<.001	.006	3	1
OESOPHAGUS	USP17L18 →	+0.050	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

DEUP1 by SLC6A12 expression — BLOOD_Lymphoma

Explore this box plot interactively →