SLC6A12

Across TCGA pan-cancer cohorts, SLC6A12 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SLC6A12 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SLC6A12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC6A12 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BLCA show a favorable association.

KIRP, UCEC, and BLCA are the cancer types where SLC6A12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.966	0.776	<.001	107	view →
UCEC	OS	Tertile	II,III,IV	0.784	0.930	<.001	70	view →
BLCA	OS	Tertile	All	0.778	0.418	<.001	48	view →
OV	OS	Tertile	II,III,IV	0.798	0.896	.006	38	view →
HNSC	DFS	Tertile	III,IV	0.402	0.260	.002	36	view →
LIHC	OS	Median	III,IV	0.761	0.472	.007	24	view →
SKCM	DFS	Quartile	II,III,IV	0.314	0.165	.003	20	view →
LUSC	DFS	Median	II,III,IV	0.611	0.858	.006	18	view →
LAML	DFS	Tertile	All	0.390	0.714	.007	16	view →
KIRC	DFS	Quartile	IV	0.750	0.360	.013	13	view →
LUAD	DFS	Median	IV	0.301	0.753	.006	12	view →
UVM	DFS	Median	II,III,IV	0.415	0.782	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SLC6A12–KIRP (OS)

Open the KIRP breakdown →