SCNN1A

Across TCGA patient cohorts, SCNN1A mutation is significantly associated with the RNA expression of many other genes, with 2,254 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1A-associated genes across cancer lineages are NEDD8-MDP1, ETFA, and RPL23AP82. Each is linked with SCNN1A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCNN1A-to-partner and partner-to-SCNN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEDD8-MDP1 grouped by SCNN1A-low versus SCNN1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1A→partner) and Y-score (partner→SCNN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NEDD8-MDP1 →	+0.303	+3.184	<.001	<.001	3	3
UCEC	ETFA →	+0.624	+2.839	<.001	.001	3	3
SKCM	RPL23AP82 →	+0.716	+2.613	<.001	.005	3	3
UCEC	LDHAP1 →	+0.136	+2.463	<.001	.001	3	3
GBM	MIR4537 →	+0.743	+5.352	<.001	.005	3	2
SKCM	RNU6-762P →	+0.554	+2.610	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,254 associations by consensus.

NEDD8-MDP1 by SCNN1A expression — UCEC

Explore this box plot interactively →