SCNN1A

Across TCGA pan-cancer cohorts, SCNN1A RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SCNN1A data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCNN1A RNA is associated with better overall survival. In most high-consensus cancer types, elevated SCNN1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, PAAD, and MESO are the cancer types where SCNN1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.847	0.672	.001	59	view →
PAAD	OS	Median	All	0.297	0.498	.003	55	view →
MESO	DFS	Quartile	All	0.541	0.256	.004	38	view →
OV	OS	Median	All	0.638	0.738	<.001	36	view →
LAML	DFS	Tertile	All	0.420	0.637	.003	28	view →
LUAD	OS	Quartile	III,IV	0.776	0.459	.014	23	view →
LGG	DFS	Tertile	All	0.770	0.882	.001	21	view →
COAD	DFS	Quartile	All	0.402	0.656	.007	20	view →
LIHC	DFS	Tertile	III,IV	0.249	0.091	.009	19	view →
THYM	OS	Quartile	All	0.861	1.000	.006	19	view →
ACC	OS	Quartile	IV	0.342	0.855	.006	18	view →
PRAD	DFS	Quartile	All	0.890	0.699	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SCNN1A–HNSC (OS)

Open the HNSC breakdown →