Q-omics provides the consensus-scored SAA3P profile across patient tissues and cancer cell-line models. SAA3P expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, SAA3P is differentially expressed in 2, with the highest sampling consensus in LUSC. Additionally, SAA3P RNA expression shows 5,987 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight UVM, LUSC, and STAD as cancer lineages where SAA3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SAA3P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SAA3P survival associations across molecular data types. SAA3P RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SAA3P RNA expression–survival associations across cancer types. High SAA3P expression shows unfavorable associations in UVM, TGCT, KICH, COAD and KIRC, but favorable associations in UCS. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for SAA3P RNA expression.
This table summarizes SAA3P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for SAA3P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SAA3P shows higher tumor expression in LUSC and STAD. The LUSC box plot shows higher SAA3P RNA expression in tumor versus normal tissue (log2 FC = +0.044, t-test p = .021).
This table shows molecular features associated with SAA3P in patient tissues and cancer cell lines. In patient samples, SAA3P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
