SAA3P

Across TCGA patient cohorts, SAA3P mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAA3P-associated genes across cancer lineages are AICDA, AMPD1, and IL21. Each is linked with SAA3P in more than 1 cancer types. Because this analysis shows association rather than direction, both SAA3P-to-partner and partner-to-SAA3P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AICDA grouped by SAA3P-low versus SAA3P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAA3P→partner) and Y-score (partner→SAA3P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AICDA →	+0.267	+3.443	.003	.005	3	1
UCEC	AMPD1 →	+0.393	+3.457	<.001	.005	3	1
UCEC	IL21 →	+0.148	+3.026	.007	.002	3	1
UCEC	IGHV3OR16-6 →	+0.806	+2.982	<.001	.006	3	1
UCEC	IGKV1OR2-118 →	+0.271	+3.496	.003	<.001	3	1
UCEC	IGHV1OR15-3 →	+0.118	+3.355	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

AICDA by SAA3P expression — UCEC

Explore this box plot interactively →