retinal outer segment membrane protein 1Genealiases: ROM · ROSP1 · RP7 · TSPAN23
Q-omics provides the consensus-scored ROM1 profile across patient tissues and cancer cell-line models. ROM1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, ROM1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, ROM1 RNA expression shows 17,011 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and KIRC as cancer lineages where ROM1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ROM1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ROM1 survival associations across molecular data types. ROM1 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ROM1 RNA expression–survival associations across cancer types. High ROM1 expression shows unfavorable associations in ACC, LGG and UVM, but favorable associations in MESO, THCA and SKCM. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for ROM1 RNA expression.
This table summarizes ROM1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for ROM1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ROM1 shows lower tumor expression in BLCA, LUAD, UCEC and KICH and higher tumor expression in KIRC and THCA. The KIRC box plot shows higher ROM1 RNA expression in tumor versus normal tissue (log2 FC = +0.500, t-test p < 0.001).
This table shows molecular features associated with ROM1 in patient tissues and cancer cell lines. In patient samples, ROM1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ROM1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BONE.
