ROM1

Across TCGA pan-cancer cohorts, ROM1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ROM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ROM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ROM1 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

KIRC, BLCA, and THCA are the cancer types where ROM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.500	<.001	10	view →
BLCA	Male	III,IV	−1.387	<.001	8	view →
THCA	Female	II,III,IV	+1.032	<.001	8	view →
LUAD	All	All	−0.293	.001	7	view →
UCEC	All	II,III,IV	−1.424	<.001	6	view →
KICH	All	All	−0.696	<.001	6	view →
LUSC	Male	II,III,IV	−0.535	<.001	6	view →
BRCA	All	II,III,IV	−0.403	<.001	4	view →
READ	All	All	−0.711	.001	3	view →
PAAD	Female	All	+0.659	.013	2	view →
BRCA	All	IV	+0.490	.033	2	view →
PRAD	All	All	−0.239	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ROM1–KIRC

Open the KIRC breakdown →