ROM1

Across TCGA patient cohorts, ROM1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROM1-associated genes across cancer lineages are ERK2, ACC_pS79, and GAPDH. Each is linked with ROM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROM1-to-partner and partner-to-ROM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ROM1-low versus ROM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROM1→partner) and Y-score (partner→ROM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.285	+2.999	.003	.035	3	1
UCEC	ACC_pS79 →	+0.348	+2.321	.045	.035	3	1
UCEC	GAPDH →	+0.529	+2.321	.049	.035	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.428	+2.179	.046	.034	3	1
UCEC	IRS1 →	-0.249	-2.321	.017	.035	3	1
UCEC	Mre11 →	-0.101	-2.321	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ERK2 by ROM1 expression — UCEC

Explore this box plot interactively →