RNASE12

Across TCGA patient cohorts, RNASE12 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible RNASE12-associated genes across cancer lineages are RNU6-777P, ATP5MFP3, and RPL7L1P5. Each is linked with RNASE12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE12-to-partner and partner-to-RNASE12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-777P grouped by RNASE12-low versus RNASE12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE12→partner) and Y-score (partner→RNASE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-777P →	+0.302	+4.495	<.001	.007	3	2
LUSC	ATP5MFP3 →	+0.192	+5.404	.002	.005	3	2
UCEC	RPL7L1P5 →	+0.158	+3.016	.006	.009	3	2
HNSC	MIR6858 →	+0.533	+5.124	<.001	.008	3	1
SKCM	OR2J3 →	+0.033	+4.614	<.001	.006	3	1
SKCM	RNA5SP207 →	+0.457	+3.765	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

RNU6-777P by RNASE12 expression — SKCM

Explore this box plot interactively →