RNASE12

Across TCGA pan-cancer cohorts, RNASE12 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNASE12’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNASE12 RNA is repressed in tumor relative to normal tissue. In most cancer types RNASE12 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

BRCA and PRAD are the cancer types where RNASE12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASE12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.060	.018	4	view →
PRAD	All	All	−0.249	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

RNASE12–BRCA

Open the BRCA breakdown →