Rho related BTB domain containing 3Genealiases: []
Q-omics provides the consensus-scored RHOBTB3 profile across patient tissues and cancer cell-line models. RHOBTB3 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, RHOBTB3 is differentially expressed in 8, with the highest sampling consensus in KIRC. Additionally, RHOBTB3 RNA expression shows 19,387 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, KIRC, and UVM as cancer lineages where RHOBTB3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RHOBTB3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RHOBTB3 survival associations across molecular data types. RHOBTB3 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RHOBTB3 RNA expression–survival associations across cancer types. High RHOBTB3 expression shows unfavorable associations in KIRP, MESO, UCEC and KIRC, but favorable associations in LAML and HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for RHOBTB3 RNA expression.
This table summarizes RHOBTB3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for RHOBTB3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RHOBTB3 shows lower tumor expression in KIRC, KIRP and KICH and higher tumor expression in THCA, LUAD and LIHC. The KIRC box plot shows higher RHOBTB3 RNA expression in normal versus tumor tissue (log2 FC = −1.758, t-test p < 0.001).
This table shows molecular features associated with RHOBTB3 in patient tissues and cancer cell lines. In patient samples, RHOBTB3 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, RHOBTB3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LIVER.
