RHOBTB3

Across TCGA cell cohorts, RHOBTB3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible RHOBTB3-associated genes across cancer lineages are GHRHR, DYDC1, and AADACL3. Each is linked with RHOBTB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOBTB3-to-partner and partner-to-RHOBTB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by RHOBTB3-low versus RHOBTB3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB3→partner) and Y-score (partner→RHOBTB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHRHR →	+0.453	+4.906	<.001	.006	3	1
OESOPHAGUS	DYDC1 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	SPDYE4 →	+0.076	+4.544	<.001	.003	3	1
BLOOD_Lymphoma	IL2 →	+0.596	+4.350	.004	.005	3	1
BLOOD_Lymphoma	DAZ1 →	+0.160	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GHRHR by RHOBTB3 expression — OESOPHAGUS

Explore this box plot interactively →