RHOBTB3

Across TCGA patient cohorts, RHOBTB3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,371 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RHOBTB3-associated genes across cancer lineages are HSPD1P11, RPS4X, and SCN1B. Each is linked with RHOBTB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both RHOBTB3-to-partner and partner-to-RHOBTB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHOBTB3 versus HSPD1P11 in BRCA, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB3→partner) and Y-score (partner→RHOBTB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPD1P11 →	+0.580	+0.506	<.001	<.001	3	4
OV	RPS4X →	-0.792	-0.577	.008	.007	3	3
BRCA	SCN1B →	+0.519	+0.345	.001	.001	3	2
LSCC	AFMID →	-0.458	-0.315	<.001	<.001	3	2
OV	MXRA5Y →	+0.627	+0.652	<.001	.001	3	2
UCEC	CKB →	+2.812	+0.884	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,371 associations by consensus.

RHOBTB3 vs HSPD1P11 — BRCA

Explore this scatter interactively →