Q-omics provides the consensus-scored RHNO1 profile across patient tissues and cancer cell-line models. RHNO1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, RHNO1 is differentially expressed in 15, with the highest sampling consensus in KIRP. Additionally, RHNO1 RNA expression shows 19,278 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KICH, KIRP, and ACC as cancer lineages where RHNO1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RHNO1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RHNO1 survival associations across molecular data types. RHNO1 RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RHNO1 RNA expression–survival associations across cancer types. High RHNO1 expression shows unfavorable associations in KICH, KIRC, MESO, LIHC and KIRP, but favorable associations in READ. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for RHNO1 RNA expression.
This table summarizes RHNO1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for RHNO1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RHNO1 shows higher tumor expression in KIRP, BLCA, KIRC, HNSC, LIHC and LUAD. The KIRP box plot shows higher RHNO1 RNA expression in tumor versus normal tissue (log2 FC = +1.622, t-test p < 0.001).
This table shows molecular features associated with RHNO1 in patient tissues and cancer cell lines. In patient samples, RHNO1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, RHNO1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BLOOD_Leukemia.
