PRKAA1

Across TCGA patient cohorts, PRKAA1 mutation is significantly associated with the RNA expression of many other genes, with 2,344 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAA1-associated genes across cancer lineages are CYCSP49, RPL5P21, and RNU6-116P. Each is linked with PRKAA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAA1-to-partner and partner-to-PRKAA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP49 grouped by PRKAA1-low versus PRKAA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAA1→partner) and Y-score (partner→PRKAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CYCSP49 →	+0.086	+4.335	.004	.005	3	2
HNSC	RPL5P21 →	+0.053	+4.505	<.001	.009	3	2
BRCA	RNU6-116P →	+0.177	+4.121	<.001	.009	3	2
BRCA	LINC01677 →	+0.056	+4.811	.001	.003	3	2
UCEC	LINC01607 →	-0.698	-3.300	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,344 associations by consensus.

CYCSP49 by PRKAA1 expression — COAD

Explore this box plot interactively →