PRKAA1

Across TCGA pan-cancer cohorts, PRKAA1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRKAA1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRKAA1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKAA1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, HNSC, and BRCA are the cancer types where PRKAA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.721	<.001	10	view →
HNSC	All	All	+0.557	<.001	7	view →
BRCA	All	All	−0.489	<.001	6	view →
LUAD	All	IV	+0.779	.007	5	view →
UCEC	All	All	−0.965	<.001	4	view →
STAD	All	All	+0.756	<.001	4	view →
PAAD	Male	All	+0.740	.005	4	view →
KICH	All	All	−0.720	.002	3	view →
CHOL	All	All	+0.694	<.001	2	view →
KIRP	Male	All	−0.356	.011	2	view →
ESCA	All	All	+0.560	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRKAA1–THCA

Open the THCA breakdown →