POU class 3 homeobox 4Genealiases: BRAIN-4 · BRN-4 · BRN4 · DFN3 · DFNX2 · OCT-9
Q-omics provides the consensus-scored POU3F4 profile across patient tissues and cancer cell-line models. POU3F4 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, POU3F4 is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, POU3F4 RNA expression shows 6,602 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRC, and STAD as cancer lineages where POU3F4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for POU3F4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes POU3F4 survival associations across molecular data types. POU3F4 RNA expression shows survival associations in the most cancer types (14), followed by mutation status (6) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible POU3F4 RNA expression–survival associations across cancer types. High POU3F4 expression shows unfavorable associations in KIRC, KIRP, READ and LIHC, but favorable associations in ESCA and UCS. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for POU3F4 RNA expression.
This table summarizes POU3F4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for POU3F4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. POU3F4 shows lower tumor expression in KIRC, KIRP, KICH, THCA, COAD and READ. The KIRC box plot shows higher POU3F4 RNA expression in normal versus tumor tissue (log2 FC = −1.493, t-test p < 0.001).
This table shows molecular features associated with POU3F4 in patient tissues and cancer cell lines. In patient samples, POU3F4 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, POU3F4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
