Across TCGA cell cohorts, POU3F4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU3F4-associated genes across cancer lineages are SLC22A8, CCDC105, and OR4D5. Each is linked with POU3F4 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU3F4-to-partner and partner-to-POU3F4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU3F4→partner) and Y-score (partner→POU3F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC22A8 →	+0.038	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	TEX49 →	+0.061	+4.544	.008	.003	3	1
LARGE_INTESTINE	VAX1 →	+0.771	+3.519	<.001	.007	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

POU3F4 survival (RNA) · tumor vs normal (RNA) · all POU3F4 data types