olfactory receptor family 14 subfamily K member 1Genealiases: OR1-39 · OR1.5.9 · OR5AY1
Q-omics provides the consensus-scored OR14K1 profile across patient tissues and cancer cell-line models. OR14K1 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, OR14K1 is differentially expressed in 5, with the highest sampling consensus in BRCA. Additionally, OR14K1 RNA expression shows 6,369 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight THCA, BRCA, and STAD as cancer lineages where OR14K1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR14K1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR14K1 survival associations across molecular data types. OR14K1 RNA expression shows survival associations in the most cancer types (18), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR14K1 RNA expression–survival associations across cancer types. High OR14K1 expression shows unfavorable associations in THCA, COAD, READ, LUSC, UCS and MESO. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for OR14K1 RNA expression.
This table summarizes OR14K1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for OR14K1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR14K1 shows lower tumor expression in THCA, COAD and KICH and higher tumor expression in BRCA and PRAD. The BRCA box plot shows higher OR14K1 RNA expression in tumor versus normal tissue (log2 FC = +0.179, t-test p = .010).
This table shows molecular features associated with OR14K1 in patient tissues and cancer cell lines. In patient samples, OR14K1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, OR14K1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and OESOPHAGUS.
