OR14K1

Across TCGA patient cohorts, OR14K1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR14K1-associated genes across cancer lineages are ERK2, Src, and Chk2_pT68. Each is linked with OR14K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR14K1-to-partner and partner-to-OR14K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by OR14K1-low versus OR14K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR14K1→partner) and Y-score (partner→OR14K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.241	+3.321	.002	.009	3	2
UCEC	Src →	-0.238	-3.321	.005	.010	3	2
UCEC	Chk2_pT68 →	-0.188	-3.433	.014	.005	3	2
SKCM	eEF2 →	+0.374	+2.824	.005	.034	3	1
SKCM	FOXO3a →	-0.112	-3.000	.018	.034	3	1
SKCM	MAPK_pT202_Y204 →	+0.526	+2.459	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ERK2 by OR14K1 expression — UCEC

Explore this box plot interactively →