POU3F4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, POU3F4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU3F4-associated genes across cancer lineages are Ku80, p90 RSK, and ARID1A. Each is linked with POU3F4 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU3F4-to-partner and partner-to-POU3F4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU3F4→partner) and Y-score (partner→POU3F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECKu80 →+0.188+1.428.010.00632
UCECp90 RSK →+0.214+2.502<.001.00132
UCECARID1A →-0.134-1.689.019.04232
UCECATM →-0.311-1.571.027.03232
UCECbeta-Catenin →+0.321+1.502.041.02732
UCECCaspase-7-cleavedD198 →+0.522+1.522.004.01732
Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration