piggyBac transposable element derived 4Genealiases: []
Q-omics provides the consensus-scored PGBD4 profile across patient tissues and cancer cell-line models. PGBD4 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, PGBD4 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, PGBD4 RNA expression shows 20,114 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and THCA as cancer lineages where PGBD4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PGBD4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PGBD4 survival associations across molecular data types. PGBD4 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PGBD4 RNA expression–survival associations across cancer types. High PGBD4 expression shows unfavorable associations in UVM, COAD and LIHC, but favorable associations in LGG, MESO and ESCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .005). Together, the overview and detailed table identify UVM as the clearest survival context for PGBD4 RNA expression.
This table summarizes PGBD4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for PGBD4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PGBD4 shows lower tumor expression in THCA, KIRC and KICH and higher tumor expression in LIHC, HNSC and LUSC. The THCA box plot shows higher PGBD4 RNA expression in normal versus tumor tissue (log2 FC = −0.641, t-test p < 0.001).
This table shows molecular features associated with PGBD4 in patient tissues and cancer cell lines. In patient samples, PGBD4 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, PGBD4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
