PGBD4

Across TCGA cell cohorts, PGBD4 mutation is significantly associated with the RNA expression of many other genes, with 206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGBD4-associated genes across cancer lineages are PNPLA3, FOXP1, and NR4A1. Each is linked with PGBD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGBD4-to-partner and partner-to-PGBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA3 grouped by PGBD4-low versus PGBD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD4→partner) and Y-score (partner→PGBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNPLA3 →	+1.186	+3.212	.001	.006	3	1
LARGE_INTESTINE	FOXP1 →	+1.584	+3.212	<.001	.006	3	1
LARGE_INTESTINE	NR4A1 →	+1.189	+3.212	.001	.006	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.654	+3.807	<.001	<.001	3	1
LARGE_INTESTINE	PKDREJ →	+0.241	+3.241	.001	.007	3	1
LARGE_INTESTINE	ZNF428 →	+0.692	+3.212	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 206 associations by consensus.

PNPLA3 by PGBD4 expression — LARGE_INTESTINE

Explore this box plot interactively →