PGBD4

Across TCGA patient cohorts, PGBD4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGBD4-associated genes across cancer lineages are INPP4B, VHL, and JNK_pT183_Y185. Each is linked with PGBD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGBD4-to-partner and partner-to-PGBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PGBD4-low versus PGBD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD4→partner) and Y-score (partner→PGBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.222	-2.115	.048	.016	3	2
UCEC	VHL →	-0.724	-1.678	.002	.021	3	2
UCEC	JNK_pT183_Y185 →	-0.163	-2.057	.005	.001	3	1
UCEC	JNK2 →	+0.148	+2.070	.031	.001	3	1
UCEC	Ku80 →	+0.191	+1.750	.019	.004	3	1
UCEC	Notch1 →	+0.138	+1.736	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

INPP4B by PGBD4 expression — UCEC

Explore this box plot interactively →