PCCB

Across TCGA patient cohorts, PCCB mutation is significantly associated with the RNA expression of many other genes, with 3,449 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCCB-associated genes across cancer lineages are MIR6090, OR4M1, and SLC39A12-AS1. Each is linked with PCCB in more than 2 cancer types. Because this analysis shows association rather than direction, both PCCB-to-partner and partner-to-PCCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6090 grouped by PCCB-low versus PCCB-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCCB→partner) and Y-score (partner→PCCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR6090 →	+0.595	+6.578	<.001	.001	3	3
SKCM	OR4M1 →	+0.030	+4.098	<.001	.001	3	2
CESC	SLC39A12-AS1 →	+0.019	+4.934	<.001	.002	3	2
CESC	MTCO3P40 →	+0.076	+4.969	<.001	.004	3	2
LUAD	RN7SKP264 →	+0.239	+5.157	<.001	.007	3	2
LUSC	RNU6-458P →	+0.378	+6.578	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,449 associations by consensus.

MIR6090 by PCCB expression — LUSC

Explore this box plot interactively →