PCCB

Across TCGA pan-cancer cohorts, PCCB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PCCB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCCB RNA is repressed in tumor relative to normal tissue. In most cancer types PCCB is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, LUSC, and HNSC are the cancer types where PCCB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCCB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.632	<.001	11	view →
LUSC	Female	All	+1.169	<.001	8	view →
HNSC	Male	III,IV	+0.693	.001	8	view →
LUAD	Female	All	+0.561	<.001	8	view →
BRCA	All	III,IV	+0.478	<.001	8	view →
UCEC	All	III,IV	+1.096	<.001	6	view →
THCA	Male	III,IV	−0.622	<.001	6	view →
KIRP	Male	All	−0.665	.005	5	view →
CHOL	All	All	−1.122	<.001	3	view →
PRAD	All	All	+0.519	<.001	2	view →
KICH	All	All	−0.457	.022	2	view →
BLCA	All	All	+0.392	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PCCB–KIRC

Open the KIRC breakdown →