P2RY11

Across TCGA patient cohorts, P2RY11 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY11-associated genes across cancer lineages are RNU4-58P, RN7SL216P, and MTND6P20. Each is linked with P2RY11 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY11-to-partner and partner-to-P2RY11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by P2RY11-low versus P2RY11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY11→partner) and Y-score (partner→P2RY11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.385	+4.133	<.001	.002	3	2
LUSC	RN7SL216P →	+0.102	+7.924	.006	.008	3	1
LUSC	MTND6P20 →	+0.073	+7.924	<.001	.008	3	1
LUSC	MIR4771-1 →	+0.352	+7.924	<.001	.008	3	1
UCEC	CFC1B →	+0.092	+4.877	<.001	.003	3	1
UCEC	MIR3168 →	+0.958	+4.048	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

RNU4-58P by P2RY11 expression — UCEC

Explore this box plot interactively →