P2RY11

Across TCGA pan-cancer cohorts, P2RY11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of P2RY11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where P2RY11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types P2RY11 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

KIRC, STAD, and COAD are the cancer types where P2RY11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RY11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.629	<.001	11	view →
STAD	Male	II,III,IV	+1.092	<.001	10	view →
COAD	All	All	+0.466	<.001	10	view →
LIHC	Female	All	+0.750	<.001	9	view →
KIRP	All	III,IV	+0.861	.001	8	view →
BRCA	All	All	+0.451	<.001	4	view →
CHOL	All	All	+1.704	<.001	3	view →
HNSC	Male	IV	+0.740	.004	2	view →
UCEC	All	All	+0.542	.021	2	view →
PRAD	All	All	+0.356	<.001	2	view →
LUSC	All	III,IV	+0.813	.038	1	view →
KICH	Female	II,III,IV	+0.621	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

P2RY11–KIRC

Open the KIRC breakdown →