NQO2

Across TCGA patient cohorts, NQO2 mutation is significantly associated with the RNA expression of many other genes, with 175 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NQO2-associated genes across cancer lineages are RNU6-1265P, MIR153-1, and RN7SKP177. Each is linked with NQO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NQO2-to-partner and partner-to-NQO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1265P grouped by NQO2-low versus NQO2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO2→partner) and Y-score (partner→NQO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1265P →	+0.459	+5.382	<.001	.003	3	2
BRCA	MIR153-1 →	+0.277	+4.540	.001	.009	3	2
BRCA	RN7SKP177 →	+0.087	+4.540	.003	.009	3	2
BRCA	BMS1P13 →	+0.079	+4.859	<.001	.002	3	2
SKCM	RNU7-196P →	+0.537	+7.816	<.001	.008	3	2
UCEC	PCNPP2 →	+0.066	+3.489	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 175 associations by consensus.

RNU6-1265P by NQO2 expression — BRCA

Explore this box plot interactively →