NQO2

Across TCGA pan-cancer cohorts, NQO2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NQO2 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher NQO2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NQO2 expression acts as an unfavorable survival marker, although some lineages such as THYM and CESC show a favorable association.

KICH, THYM, and MESO are the cancer types where NQO2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.596	0.955	.003	52	view →
THYM	DFS	Tertile	II,III,IV	0.964	0.566	.001	49	view →
MESO	OS	Quartile	II,III,IV	0.225	0.459	.014	39	view →
LIHC	OS	Tertile	All	0.699	0.841	.001	37	view →
GBM	OS	Tertile	All	0.307	0.458	.007	24	view →
LGG	OS	Quartile	All	0.318	0.547	.008	20	view →
SKCM	DFS	Tertile	All	0.554	0.664	.007	20	view →
UVM	DFS	Quartile	III,IV	0.580	1.000	.003	19	view →
CESC	DFS	Quartile	IV	0.690	0.301	.034	16	view →
BRCA	DFS	Median	All	0.880	0.922	.005	15	view →
UCS	OS	Tertile	IV	0.241	1.000	.036	12	view →
ESCA	OS	Quartile	III,IV	0.265	0.684	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NQO2–KICH (DFS)

Open the KICH breakdown →