NQO2

Across TCGA pan-cancer cohorts, NQO2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NQO2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NQO2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NQO2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

COAD, KIRP, and STAD are the cancer types where NQO2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NQO2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.246	<.001	11	view →
KIRP	All	III,IV	−1.250	<.001	9	view →
STAD	Male	II,III,IV	+0.983	<.001	9	view →
KICH	All	II,III,IV	−1.229	<.001	7	view →
LIHC	Male	All	+0.727	<.001	7	view →
THCA	Male	III,IV	−0.391	.001	6	view →
HNSC	All	All	+0.326	.003	6	view →
LUAD	All	All	+0.308	.001	5	view →
READ	All	All	+0.613	.004	4	view →
KIRC	All	II,III,IV	+0.350	.024	2	view →
BRCA	All	II,III,IV	−0.156	.032	2	view →
ESCA	All	All	+0.705	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NQO2–COAD

Open the COAD breakdown →