Q-omics provides the consensus-scored MIR153-1 profile across patient tissues and cancer cell-line models. MIR153-1 expression is associated with patient survival in 10 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, MIR153-1 is differentially expressed in 1, with the highest sampling consensus in THCA. Additionally, MIR153-1 RNA expression shows 8,030 significant gene co-expression associations, with the highest sampling consensus in PAAD. Together, these results highlight THCA, and PAAD as cancer lineages where MIR153-1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR153-1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR153-1 survival associations across molecular data types. MIR153-1 RNA expression shows survival associations in the most cancer types (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR153-1 RNA expression–survival associations across cancer types. High MIR153-1 expression shows unfavorable associations in THCA, ACC, LUAD, UCEC and LUSC, but favorable associations in PAAD. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for MIR153-1 RNA expression.
This table summarizes MIR153-1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MIR153-1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR153-1 shows lower tumor expression in THCA. The THCA box plot shows higher MIR153-1 RNA expression in normal versus tumor tissue (log2 FC = −0.105, t-test p = .005).
This table shows molecular features associated with MIR153-1 in patient tissues and cancer cell lines. In patient samples, MIR153-1 shows the broadest associations at the RNA and protein expression levels, with PAAD recurring as the lineage with the largest associated feature set.
