NPC2

Across TCGA patient cohorts, NPC2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPC2-associated genes across cancer lineages are RN7SL248P, COX6CP3, and MIR8059. Each is linked with NPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPC2-to-partner and partner-to-NPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NPC2-low versus NPC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC2→partner) and Y-score (partner→NPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.139	+4.722	<.001	.004	3	1
UCEC	COX6CP3 →	+0.337	+3.677	<.001	.006	3	1
UCEC	MIR8059 →	+0.747	+3.801	<.001	.004	3	1
BLCA	MRPL51P2 →	+0.114	+7.640	<.001	.009	3	1
UCEC	RN7SKP214 →	+0.719	+3.334	<.001	.008	3	1
UCEC	RNY4P3 →	+0.436	+3.418	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RN7SL248P by NPC2 expression — UCEC

Explore this box plot interactively →