NPC2

Across TCGA pan-cancer cohorts, NPC2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NPC2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NPC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPC2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where NPC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.524	<.001	11	view →
HNSC	Female	III,IV	+1.214	<.001	11	view →
KIRC	Female	All	+0.456	<.001	11	view →
LIHC	Female	II,III,IV	+1.404	<.001	9	view →
LUSC	Male	II,III,IV	−1.888	<.001	8	view →
LUAD	Male	III,IV	−1.655	<.001	7	view →
KIRP	Male	All	+0.802	<.001	6	view →
STAD	All	All	+0.565	<.001	6	view →
ESCA	All	All	+0.787	.002	4	view →
KICH	Female	All	+0.669	.005	4	view →
CHOL	All	All	+1.206	<.001	2	view →
UCEC	All	All	+0.607	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NPC2–THCA

Open the THCA breakdown →