NPC2

Across TCGA pan-cancer cohorts, NPC2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NPC2 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher NPC2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NPC2 expression acts as an unfavorable survival marker, although some lineages such as THCA and BRCA show a favorable association.

THCA, BRCA, and READ are the cancer types where NPC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	II,III,IV	0.868	0.607	.001	69	view →
BRCA	DFS	Median	All	0.587	0.474	<.001	64	view →
READ	DFS	Tertile	III,IV	0.197	0.491	.004	53	view →
STAD	OS	Quartile	All	0.483	0.718	<.001	51	view →
LIHC	OS	Tertile	All	0.408	0.638	<.001	51	view →
ACC	DFS	Tertile	All	0.247	0.719	<.001	48	view →
LUAD	OS	Median	All	0.867	0.757	<.001	48	view →
LGG	OS	Median	All	0.373	0.521	<.001	45	view →
GBM	DFS	Median	All	0.150	0.255	.002	32	view →
HNSC	OS	Tertile	All	0.678	0.803	.002	30	view →
LUSC	DFS	Quartile	All	0.678	0.806	.001	27	view →
LAML	DFS	Tertile	All	0.242	0.584	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NPC2–THCA (DFS)

Open the THCA breakdown →