Q-omics provides the consensus-scored NDUFS5 profile across patient tissues and cancer cell-line models. NDUFS5 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, NDUFS5 is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, NDUFS5 protein abundance shows 19,313 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KICH, KIRC, and GBM as cancer lineages where NDUFS5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NDUFS5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NDUFS5 survival associations across molecular data types. NDUFS5 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (1) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NDUFS5 RNA expression–survival associations across cancer types. High NDUFS5 expression shows unfavorable associations in KICH, LIHC, LGG and UCS, but favorable associations in SCLC and OV. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KICH as the clearest survival context for NDUFS5 RNA expression.
This table summarizes NDUFS5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for NDUFS5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NDUFS5 shows higher tumor expression in KIRC, KIRP, LIHC, LUSC, LUAD and UCEC. The KIRC box plot shows higher NDUFS5 RNA expression in tumor versus normal tissue (log2 FC = +0.559, t-test p < 0.001).
This table shows molecular features associated with NDUFS5 in patient tissues and cancer cell lines. In patient samples, NDUFS5 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, NDUFS5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in BREAST and BLOOD_Leukemia.
